He stressed that cause-and-effect wasn’t confirmed. However, Thongprayoon believes that doctors “should consider whether PPI therapy is indicated for patients. Chronic use of PPIs should be avoided if not really indicated.”
Two kidney specialists said the new research does have value.
“It is important to always evaluate potential side effects — not only of medications but of treatments and procedures in general,” said Dr. Ernesto Molmenti. He directs adult and pediatric kidney transplantation at Northwell Health in Manhasset, N.Y.
Dr. Maria DeVita helps direct kidney care at Lenox Hill Hospital in New York City. She noted that PPIs — some of which have gained over-the-counter status in recent years — “are one of the most commonly ingested medications worldwide.”
Also, DeVita said, “PPIs were originally used for a limited time, but now, people may continue to use them for years.”
While it remains to be proven that the drugs cause kidney trouble, “we should reconsider our prolonged use of PPIs from time to time to make sure that the benefits outweigh potential risks,” she said.
Experts note that findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.
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