When you take these painkillers, they can affect your vital organs. These can affect your liver, especially if taken frequently or when combined with alcohol. An estimated 1 in 100,000 cases of people abusing painkillers can end up having an acute liver injury.
NSAID’s reduce the blood flow to the kidneys, which make them work slower. If you take NSAID’s in high doses, the reduced blood flow can permanently damage your kidneys and you can have kidney failure.
These painkillers can also cause ulcers and other problems in your esophagus, stomach, or small intestine. NSAID’s prevent the creation of prostaglandins, the chemical that causes swelling and increases pain. They also protect the lining of the stomach and the GI tract and when these NSAID’s slow down prostaglandin, then you could have gastrointestinal problems.
People that have chronic pain should visit their doctor so that they can monitor your pain medicine. Please don’t take matters into your own hands and self-medicate. It’s critically dangerous and you can cause serious damage to your health.