People who are deficient in iron usually don’t consume enough of the mineral in their diet or can’t process the iron they do get, he said. Iron-rich foods include meat; poultry; eggs; seafood, including tuna, scallops and shrimp; vegetables such as spinach and sweet potatoes, and beans, according to the American Red Cross. Other good dietary sources include enriched breads and pasta, and fruits like strawberries and watermelon.
“Iron supplementation per se plays a minor role, as long as the overall uptake is sufficient,” Schrage said. “However, some individuals might not be able to absorb enough iron via the intestines. For these individuals, intravenous iron therapy might be an option.”
Earlier studies have found that iron-deficient patients with cardiovascular diseases are more likely than others to be hospitalized or die. Giving intravenous iron improved symptoms, function and quality of life in heart failure patients with iron deficiency, the researchers noted.
The current study included more than 12,000 European men and women with a median age of 59. Over roughly 13 years, the researchers looked for heart disease and stroke, death due to cardiovascular disease and death from any cause.
At the study’s start, almost two-thirds of the participants had what’s called functional iron deficiency. This means they have enough iron, but not enough in the blood for the body to work properly, Schrage said. These individuals were more likely to develop heart disease and were also more likely to die during the next 13 years, he said.
During follow-up, 18% of the participants died, 5% of them from cardiovascular disease. Also, 9% were diagnosed with heart disease and 6% with stroke.
Iron deficiency was tied to a 24% higher risk of heart disease, a 26% increased risk of dying from cardiovascular disease and a 12% higher risk of dying from any cause, compared with no iron deficiency, the researchers found.
When Schrage and his colleagues calculated the effect of iron deficiency over 10 years, they found that 5% of all deaths, 12% of cardiovascular deaths and 11% of new heart disease diagnoses could be attributed to iron deficiency.
But don’t rush out and buy iron supplements just yet, according to a heart expert not involved with the study.
Dr. Gregg Fonarow, director of the Ahmanson-UCLA Cardiomyopathy Center, said there is mixed evidence about the connection between iron and heart disease.
“There is clinical trial evidence which demonstrates patients with heart failure and iron deficiency derive benefit from intravenous iron treatment,” he said. “There is no comparable data supporting oral iron supplementation in heart failure.”
