mice. They believe RAGE evolved to help keep ancient humans from starving when food was scarce.
But today, in times of plenty, there’s a glitch at work: RAGE is produced to combat the cellular stress caused by overeating.
The protein seems to mistake this stress as similar to starvation, and so it switches off the body’s ability to burn fat. The result: fat becomes easy to accumulate, but tough to shed.
Still, there’s a silver lining to all of this, the NYU team said, because the research might lead to anti-obesity drugs.
“Our thinking is that RAGE is targetable. When we put mice with no RAGE expression at all on a high-fat diet, they ate the food but were
